Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PLEC | Q15149 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9855569 | 0.74 | CA12 (0.40) | PTPN1CES2CES1NPC1RAB9A | |
| SCHEMBL30578088 | 0.69 | PTPN1 (0.60) | PTPN1CES2CES1MAOAMAOB | |
| SCHEMBL9855299 | 0.68 | CES2 (0.41) | PTPN1CES2CES1NPC1RAB9A | |
| SCHEMBL9855625 | 0.68 | PTPN1 (0.48) | PTPN1CES2CES1MAOAMAOB | |
| SCHEMBL2175225 | 0.66 | PTPN1 (0.56) | PTPN1CES2CES1MAOAMAOB | |
| SCHEMBL10327311 | 0.66 | PTPN1 (1.00) | PTPN1CES2CES1NPC1RAB9A | |
| SCHEMBL120278 | 0.66 | PTPN1 (1.00) | PTPN1CES2CES1NPC1RAB9A | |
| SCHEMBL9855130 | 0.64 | CES2 (0.41) | PTPN1CES2CES1NPC1RAB9A | |
| SCHEMBL6168439 | 0.64 | PLOD2 (0.56) | PTPN1CES2CES1NPC1RAB9A | |
| SCHEMBL9860016 | 0.64 | PTPN1 (0.43) | PTPN1CES2CES1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011947-A | Enzyme inhibitors for cholesterol biosythesis | BRISTOL-MYERS (US) | 1991-04-30 | — | — | US | disclosed |