Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | AKR1B10 | O60218 | 5/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.60 |
| ▸ | CA6 | P23280 | 1/20 | 0.60 |
| ▸ | CA5A | P35218 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9855964 | 1.00 | LMNA (0.71) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL6746068 | 0.91 | LMNA (0.61) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL6746067 | 0.91 | LMNA (0.61) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL15673280 | 0.89 | LMNA (0.63) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL10071614 | 0.89 | LMNA (0.63) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL1192078 | 0.89 | LMNA (0.63) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL6926334 | 0.88 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL6926335 | 0.88 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL19279512 | 0.88 | AKR1B10 (0.83) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL9277968 | 0.88 | AKR1B10 (0.83) | LMNAAKR1B10AKR1B1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263492-B1 | RETINOIDS, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | claimed |
| US-4900478-A | SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | claimed |
| US-4435496-A | WITH FREE RADICAL PHOTOSENSITIZER | AMERICAN HOECHST CORPORATION (US) | 1984-03-06 | — | — | US | claimed |
| US-4900478-A | SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | disclosed |