Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31336166 | 0.78 | ADORA2B (0.51) | ADORA2BRAB9ASMN1; SMN2KMT2AXDH | |
| SCHEMBL6358016 | 0.77 | PNP (0.57) | ADORA2BMAPTKMT2AXDH | |
| SCHEMBL7326384 | 0.76 | MAPT (0.43) | ADORA2BMAPTPOLBXDHALDH1A1 | |
| SCHEMBL6267424 | 0.76 | PNP (0.64) | — | |
| SCHEMBL7035603 | 0.75 | ADORA2B (0.55) | ADORA2BMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4014478 | 0.72 | MAPT (0.40) | ADORA2BMAPTXDHALDH1A1HPGD | |
| SCHEMBL31438586 | 0.72 | MAPT (0.48) | ADORA2BMAPTRAB9AMEN1KMT2A | |
| SCHEMBL7530553 | 0.69 | MAPT (0.46) | ADORA2BMAPTRAB9AXDHALDH1A1 | |
| SCHEMBL5849893 | 0.69 | MAPT (0.78) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL380136 | 0.69 | MAPT (0.48) | ADORA2BMAPTL3MBTL1XDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005929-A1 | PIPERIDINE DERIVATIVE AND ITS USE FOR THE TREATMENT OF DIABETS AND OBESITY | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| US-20100144613-A1 | Combined use of DPP-IV Inhibitors and Gastrin Compounds | WARATAH PHARMACEUTICALS, INC. (CA) | 2010-06-10 | — | — | US | disclosed |
| US-20090054314-A1 | Combined use of DPP-IV inhibitors and gastrin compounds | WARATAH PHARMACEUTICALS INC. (CA) | 2009-02-26 | — | — | US | disclosed |
| WO-2004018467-A3 | PHENACYL XANTHINE DERIVATIVES AS DPP-IV INHIBITOR | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-05-13 | — | — | WO | disclosed |
| WO-2004018467-A2 | PHENACYL XANTHINE DERIVATIVES AS DPP-IV INHIBITOR | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | WO | disclosed |