Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9857132 | 0.99 | SLC6A4 (0.59) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9857396 | 0.94 | SLC6A4 (0.54) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9857370 | 0.87 | SLC6A9 (0.45) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9856914 | 0.87 | HTR2A (0.49) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9857406 | 0.85 | CYP2D6 (0.52) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL8384207 | 0.85 | HTR2A (0.60) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9856731 | 0.84 | SLC6A4 (0.55) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9857294 | 0.82 | HTR2A (0.53) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9857112 | 0.82 | HTR2A (0.53) | SLC6A4MEN1KMT2ASLC6A2LMNA | |
| SCHEMBL9856505 | 0.82 | HTR2A (0.53) | SLC6A4MEN1KMT2ASLC6A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | claimed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | claimed |
| JP-2000235-A | — | — | None | — | — | JP | disclosed |
| EP-4252748-A1 | A SPHINGOSINE-1-PHOSPHATE RECEPTOR (S1PR) MODULATOR FOR USE IN TREATING A PATIENT SUFFERING FROM ALZHEIMER'S DEMENTIA | Otto-von-Guericke-University Magdeburg (DE) | 2023-10-04 | — | — | EP | disclosed |
| EP-2029566-B1 | NOVEL SEROTONIN REUPTAKE INHIBITORS AS DRUGS HAVING PERIPHERAL-SYSTEM-RESTRICTED ACTIVITY | UNIV RAMOT (IL) | 2011-04-27 | — | — | EP | disclosed |
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| JP-H02235-A | SEROTONIN AND NOREPINEPHRINE UPTAKE INHIBITOR OF 3,4-DIPHENYLBUTANAMINES | ELI LILLY & CO | 1990-01-05 | — | — | JP | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |