Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856731 | 0.80 | SLC6A4 (0.55) | TAAR1POLBSLC6A4SLC6A2HTR2A | |
| SCHEMBL9592071 | 0.74 | TRPA1 (0.43) | NOS2OPRM1OPRL1LMNAHTT | |
| SCHEMBL9857250 | 0.71 | NOS2 (0.38) | SLC6A4SLC6A2NOS2HTR2ALMNA | |
| SCHEMBL9856696 | 0.71 | HTR2A (0.43) | TAAR1SLC6A4SLC6A2HTR2AHRH1 | |
| SCHEMBL9856936 | 0.71 | SLC6A4 (0.55) | TAAR1SLC6A4SLC6A2NOS2HTR2A | |
| SCHEMBL5076835 | 0.71 | TAAR1 (0.47) | TAAR1SLC6A4NOS2HTR2AHRH1 | |
| SCHEMBL5071529 | 0.71 | TAAR1 (0.47) | TAAR1SLC6A4NOS2HTR2AHRH1 | |
| SCHEMBL9857145 | 0.70 | SLC6A4 (0.48) | SLC6A4SLC6A2NOS2HTR2AHRH1 | |
| Bromide SCHEMBL9857083 | 0.69 | HTR2A (0.38) | TAAR1SLC6A4SLC6A2HTR2AHRH1 | |
| SCHEMBL9856737 | 0.68 | SLC6A4 (0.54) | TAAR1POLBSLC6A4SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |