Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HRH1 | P35367 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857086 | 0.87 | HTR2A (0.53) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856513 | 0.82 | TAAR1 (0.53) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856891 | 0.78 | HTR2A (0.53) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856826 | 0.77 | TAAR1 (0.53) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856563 | 0.77 | TAAR1 (0.53) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856705 | 0.76 | HTR2A (0.47) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856905 | 0.76 | HTR2A (0.41) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9857006 | 0.75 | HTR2A (0.50) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9856580 | 0.75 | HTR2A (0.43) | HTR2AHRH1SLC6A4CYP2D6CHRM2 | |
| SCHEMBL9857222 | 0.74 | HTR2A (0.49) | HTR2AHRH1SLC6A4CYP2D6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |