Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856513 | 0.83 | TAAR1 (0.53) | HTR2AHRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL9856736 | 0.76 | HTR2A (0.46) | HTR2AHRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL9857086 | 0.73 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9856891 | 0.73 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9857068 | 0.73 | SLC6A4 (0.47) | HTR2AHRH1SLC6A4HRH3LMNA | |
| SCHEMBL9856862 | 0.72 | HTR2A (0.49) | HTR2AHRH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9856826 | 0.72 | TAAR1 (0.53) | HTR2AHRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL9856563 | 0.72 | TAAR1 (0.53) | HTR2AHRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL9856705 | 0.71 | HTR2A (0.47) | HTR2AHRH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9857006 | 0.71 | HTR2A (0.50) | HTR2AHRH1TAAR1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |