Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8384207 | 0.85 | HTR2A (0.60) | TAAR1SIGMAR1HTR2AHRH1SLC6A4 | |
| SCHEMBL9857077 | 0.84 | HTR2A (0.49) | TAAR1HTR2AHRH1SLC6A4SLC6A2 | |
| SCHEMBL9856887 | 0.84 | HTR2A (0.49) | TAAR1HTR2AHRH1SLC6A4SLC6A2 | |
| SCHEMBL9857036 | 0.84 | HTR2A (0.49) | TAAR1HTR2AHRH1SLC6A4SLC6A2 | |
| SCHEMBL9856737 | 0.83 | SLC6A4 (0.54) | TAAR1HTR2AHRH1SLC6A4SLC6A2 | |
| SCHEMBL9856913 | 0.82 | HTR2A (0.46) | TAAR1SIGMAR1HTR2AHRH1SLC6A4 | |
| SCHEMBL9856490 | 0.81 | CHRM2 (0.56) | TAAR1SLC6A4SLC6A2CYP2D6 | |
| SCHEMBL9856758 | 0.81 | HTR2A (0.45) | TAAR1HTR2AHRH1SLC6A4SLC6A2 | |
| SCHEMBL9857406 | 0.80 | CYP2D6 (0.52) | SIGMAR1HTR2AHRH1SLC6A4SLC6A2 | |
| SCHEMBL9857018 | 0.79 | SLC6A4 (0.46) | HTR2AHRH1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |