Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | CASR | P41180 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857018 | 0.87 | SLC6A4 (0.46) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL9856763 | 0.85 | SLC6A4 (0.44) | ALDH1A1SLC6A4CYP2D6 | |
| SCHEMBL9856612 | 0.85 | ALDH1A1 (0.61) | ALDH1A1SLC6A4SLC6A2CASRCYP2D6 | |
| SCHEMBL9857051 | 0.85 | ALDH1A1 (0.69) | ALDH1A1SLC6A4SLC6A2CYP2D6 | |
| SCHEMBL27499005 | 0.83 | TAAR1 (0.56) | MTNR1AMTNR1BTAAR1ALDH1A1SLC6A4 | |
| SCHEMBL8384207 | 0.82 | HTR2A (0.60) | CHRM1MTNR1AMTNR1BTAAR1ALDH1A1 | |
| SCHEMBL9857077 | 0.82 | HTR2A (0.49) | CHRM1MTNR1AMTNR1BTAAR1SLC6A4 | |
| SCHEMBL9856887 | 0.82 | HTR2A (0.49) | CHRM1MTNR1AMTNR1BTAAR1SLC6A4 | |
| SCHEMBL9857036 | 0.82 | HTR2A (0.49) | CHRM1MTNR1AMTNR1BTAAR1ALDH1A1 | |
| SCHEMBL9857075 | 0.81 | CALM1 (0.54) | MTNR1AMTNR1BTAAR1ALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |