Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.42 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL9856915 | 0.78 | HTR2A (0.45) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| Sulfuric Acid SCHEMBL9856918 | 0.78 | HTR2A (0.45) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL9857236 | 0.77 | HTR2A (0.53) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL9857056 | 0.76 | HTR2A (0.51) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL9856916 | 0.74 | HTR2A (0.54) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL9856790 | 0.74 | HPGD (0.39) | CYP1A2CYP2D6ALOX15TSHRCYP2C19 | |
| SCHEMBL14526719 | 0.74 | HTR2A (0.53) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL8263713 | 0.74 | HTR2A (0.53) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL9856722 | 0.73 | HTR2A (0.51) | TP53CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL9856889 | 0.73 | TAAR1 (0.53) | TP53CYP1A2CYP2D6ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |