Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.35 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.35 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL9856918 | 1.00 | HTR2A (0.45) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL9857236 | 0.83 | HTR2A (0.53) | HTR2AHRH1KMT2ALMNAPMP22 | |
| Lactic Acid SCHEMBL9856782 | 0.78 | TP53 (0.44) | HTR2AHRH1ALDH1A1HPGDSLC6A4 | |
| SCHEMBL9856916 | 0.77 | HTR2A (0.54) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL9856589 | 0.77 | CYP2D6 (0.44) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL14526719 | 0.77 | HTR2A (0.53) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL8263713 | 0.77 | HTR2A (0.53) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL9857112 | 0.77 | HTR2A (0.53) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL9856722 | 0.76 | HTR2A (0.51) | HTR2AHRH1KMT2ALMNAPMP22 | |
| SCHEMBL9856889 | 0.76 | TAAR1 (0.53) | HTR2AHRH1KMT2ALMNAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |