Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.52 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14075254 | 0.85 | PLK1 (0.75) | PLK1NR1H4TP53TSHR | |
| SCHEMBL9856997 | 0.83 | PLK1 (0.59) | PLK1NR1H4ACAT1MAPTTP53 | |
| SCHEMBL9713320 | 0.81 | PLK1 (0.64) | PLK1NR1H4ACAT1RAB9ATSHR | |
| SCHEMBL9129427 | 0.80 | PLK1 (0.61) | PLK1NR1H4ACAT1RAB9A | |
| SCHEMBL9503292 | 0.77 | PLK1 (0.65) | PLK1NR1H4MAPTTP53TSHR | |
| SCHEMBL9132805 | 0.77 | PLK1 (0.59) | PLK1NR1H4ACAT1ADRA1DADRA1A | |
| SCHEMBL9131621 | 0.77 | PLK1 (0.56) | PLK1NR1H4ACAT1 | |
| SCHEMBL9713903 | 0.76 | PLK1 (0.74) | PLK1NR1H4ACAT1MAPTTP53 | |
| SCHEMBL9502439 | 0.76 | MAPT (0.62) | PLK1NR1H4ACAT1MAPTTP53 | |
| SCHEMBL22825227 | 0.76 | PLK1 (0.67) | PLK1NR1H4ACAT1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |