Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.52 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857003 | 0.91 | SMPD1 (0.58) | PLK1NR1H4TP53NPC1MAPT | |
| SCHEMBL9856966 | 0.83 | PLK1 (0.59) | PLK1NR1H4ACAT1TP53NPC1 | |
| SCHEMBL9129427 | 0.82 | PLK1 (0.61) | PLK1NR1H4ACAT1RAB9A | |
| SCHEMBL9132489 | 0.82 | PLK1 (0.60) | PLK1NR1H4ACAT1TP53LMNA | |
| SCHEMBL9130744 | 0.82 | PLK1 (0.60) | PLK1NR1H4ACAT1TP53LMNA | |
| SCHEMBL9135710 | 0.80 | PLK1 (0.58) | PLK1NR1H4ACAT1TP53NPC1 | |
| SCHEMBL14075254 | 0.79 | PLK1 (0.75) | PLK1NR1H4TP53TSHR | |
| SCHEMBL9713320 | 0.77 | PLK1 (0.64) | PLK1NR1H4ACAT1RAB9ATSHR | |
| SCHEMBL9713903 | 0.76 | PLK1 (0.74) | PLK1NR1H4ACAT1TP53NPC1 | |
| SCHEMBL11319357 | 0.76 | PLK1 (0.66) | PLK1NR1H4ACAT1TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |