Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.55 |
| ▸ | MPEG1 | Q2M385 | 11/20 | 0.55 |
| ▸ | XIAP | P98170 | 2/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273093 | 1.00 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL9444208 | 1.00 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL10337077 | 1.00 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL30245093 | 1.00 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL29879118 | 1.00 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL30996030 | 1.00 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL11018274 | 0.90 | ALOX5 (0.47) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL27969646 | 0.89 | ALDH1A1 (0.67) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL29435920 | 0.89 | ALDH1A1 (0.67) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL9713924 | 0.86 | APAF1 (0.56) | ALDH1A1MAPTKDM4EMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5053418-A | Synergistic mixture of 2-(4,-(4-chlorophenyl)cyclohexyl)3-hydr oxy-1,4 napthoquinone and 3,5-dichloro-2,6 dichloropyridinol | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123239-B1 | IMPROVEMENTS IN OR RELATING TO ANTIPROTOZOAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0401875-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-12-12 | — | — | EP | disclosed |
| US-4970328-A | MITICIDE, FUNGICIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-13 | — | — | US | disclosed |
| EP-0300218-A1 | Use of substituted 1,4-naphthoquinones against nites and fungi | BAYER AG (DE) | 1989-01-25 | — | — | EP | disclosed |
| EP-0123239-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |