Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498168 | 0.77 | SMN1; SMN2 (0.76) | PKMSMN1; SMN2POLBCYP3A4NPSR1 | |
| SCHEMBL10447316 | 0.75 | PKM (0.56) | PKMSMN1; SMN2USP2CYP3A4NPSR1 | |
| SCHEMBL15438170 | 0.74 | POLB (0.58) | POLBUSP2NPSR1ALDH1A1TSHR | |
| SCHEMBL5076070 | 0.74 | POLB (1.00) | POLBUSP2NPSR1ALDH1A1HTT | |
| SCHEMBL28470334 | 0.74 | USP2 (0.62) | POLBUSP2NPSR1ALDH1A1TSHR | |
| SCHEMBL203679 | 0.73 | ALDH1A1 (0.61) | PKMSMN1; SMN2CYP3A4NPSR1ALDH1A1 | |
| SCHEMBL1501229 | 0.72 | PKM (0.54) | PKMSMN1; SMN2CYP3A4NPSR1ALDH1A1 | |
| SCHEMBL331731 | 0.72 | PKM (0.49) | PKMSMN1; SMN2POLBUSP2CYP3A4 | |
| Hydrochloric Acid SCHEMBL25259767 | 0.71 | ALDH1A1 (0.59) | PKMSMN1; SMN2CYP3A4NPSR1ALDH1A1 | |
| SCHEMBL5823328 | 0.71 | TSHR (0.44) | PKMSMN1; SMN2CYP3A4NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |