Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA9 | Q16790 | 4/20 | 0.52 |
| ▸ | CA6 | P23280 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30702634 | 0.93 | CA12 (0.56) | EGFRALOX5CA12CA1CA2 | |
| SCHEMBL11739990 | 0.93 | CA12 (0.56) | EGFRALOX5CA12CA1CA2 | |
| SCHEMBL27731498 | 0.88 | ALDH1A1 (0.56) | EGFRALOX5CA12CA1CA2 | |
| SCHEMBL29772126 | 0.87 | BACE1 (0.58) | EGFRCA12CA1CA2CA9 | |
| SCHEMBL901046 | 0.87 | BACE1 (0.58) | EGFRCA12CA1CA2CA9 | |
| SCHEMBL68984 | 0.87 | ALOX5 (0.71) | ALOX5BACE1KDM4EMAPTMEN1 | |
| SCHEMBL29458798 | 0.87 | ALOX5 (0.71) | ALOX5BACE1KDM4EMAPTMEN1 | |
| Acetic Acid SCHEMBL9513783 | 0.85 | ALOX5 (0.59) | ALOX5CA12CA1CA2CA9 | |
| Acetic Acid SCHEMBL9276983 | 0.85 | ALOX5 (0.59) | ALOX5CA12CA1CA2CA9 | |
| SCHEMBL10479736 | 0.85 | BACE1 (0.56) | EGFRCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429654-A1 | LIQUID-CRYSTAL POLYESTER CONTAINER AND MANUFACTURE THEREOF | TOYO SEIKAN KAISHA, LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |
| EP-0314785-A1 | BIAXIALLY ORIENTED POLYESTER FILM | TORAY INDUSTRIES, INC. (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4798875-A | POLYESTER BLEND | TORAY INDUSTRIES, INC. (JP) | 1989-01-17 | — | — | US | disclosed |
| US-4699746-A | Process of making high tenacity as-spun anisotropic melt fibers | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-10-13 | — | — | US | disclosed |
| US-4612362-A | Thermotropic polyester-carbonates containing 2,2-dimethyl-1,3-propanediol | ALLIED CORPORATION (US) | 1986-09-16 | — | — | US | disclosed |
| US-4612154-A | Spinning of certain high molecular weight anisotropic melt forming polyesters | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-09-16 | — | — | US | disclosed |
| EP-0165073-A2 | Improved spinning process | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |
| US-4435561-A | Temperature stable thermotropic poly(ester carbonate) containing high amounts of readily available diols | ALLIED CORPORATION (US) | 1984-03-06 | — | — | US | disclosed |
| US-4398018-A | Temperature stable thermotropic poly(ester carbonate) derived from t-butylhydroquinone | ALLIED CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |