Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857547 | 0.95 | TSHR (0.47) | TDP1TSHRBCHEACHEFAAH | |
| SCHEMBL15704679 | 0.83 | TDP1 (0.53) | TDP1KDM4ETSHRL3MBTL1BCHE | |
| SCHEMBL9131007 | 0.83 | TDP1 (0.53) | TDP1KDM4ETSHRL3MBTL1BCHE | |
| SCHEMBL9117410 | 0.81 | IDO1 (0.52) | TDP1MEN1KMT2A | |
| SCHEMBL12459724 | 0.81 | IDO1 (0.52) | TDP1MEN1KMT2A | |
| SCHEMBL2196874 | 0.81 | TDP1 (0.51) | TDP1KDM4ETSHRL3MBTL1BCHE | |
| SCHEMBL9857423 | 0.80 | IDO1 (0.47) | MEN1KMT2A | |
| SCHEMBL4964059 | 0.79 | PAM (0.51) | TDP1KDM4ETSHRL3MBTL1BCHE | |
| SCHEMBL1305900 | 0.77 | MMP1 (0.47) | TDP1KDM4ETSHRL3MBTL1MEN1 | |
| SCHEMBL1305901 | 0.77 | MMP1 (0.47) | TDP1KDM4ETSHRL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301401-B1 | LEUKOTRIENE ANTAGONISTS, PROCESS FOR THEIR PREPARATION, THEIR USE IN THE TREATMENT OF ILLNESSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-27 | — | — | EP | disclosed |
| EP-0301401-A2 | Leukotriene antagonists, process for their preparation, their use in the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-01 | — | — | EP | disclosed |