Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706509 | 0.81 | POLB (0.54) | KMT2AGAAPOLBF2PRSS1 | |
| SCHEMBL10728018 | 0.77 | F2 (0.58) | KMT2AGAAPOLBF2PRSS1 | |
| SCHEMBL26324738 | 0.77 | F2 (0.53) | KMT2AGAAPOLBF2PRSS1 | |
| SCHEMBL12871278 | 0.76 | LMNA (0.49) | KMT2AGAAPOLBF2PRSS1 | |
| SCHEMBL15705594 | 0.76 | LMNA (0.49) | KMT2AGAAPOLBF2PRSS1 | |
| SCHEMBL9652368 | 0.74 | KMT2A (0.54) | KMT2AGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6891327 | 0.73 | F2 (0.61) | KMT2AGAAF2PRSS1PRSS2 | |
| SCHEMBL8519402 | 0.70 | F2 (0.53) | KMT2AF2PRSS1PRSS2PRSS3 | |
| SCHEMBL8429974 | 0.70 | F2 (0.49) | KMT2AGAAPOLBF2PRSS1 | |
| SCHEMBL2178479 | 0.70 | KMT2A (0.78) | KMT2AGAAALDH1A1LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010189-A | Processes for the preparation of 5-amino-4-hydroxy-valeric acid derivatives | CIBA-GEIGY CORPORATION (US) | 1991-04-23 | — | — | US | disclosed |
| US-4898977-A | Processes for the preparation of 5-amino-4-hydroxyvaleric acid derivatives | CIBA-GEIGY CORPORATION (US) | 1990-02-06 | — | — | US | disclosed |