Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | AHCY | P23526 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857628 | 0.86 | FGFR1 (0.61) | FGFR1SLC22A6CYP3A4ENPP1 | |
| SCHEMBL9417176 | 0.83 | FGFR1 (0.51) | FGFR1SLC22A6HPRT1NT5ECYP3A4 | |
| SCHEMBL9858115 | 0.82 | HPRT1 (0.63) | HPRT1POLBPNP | |
| SCHEMBL9858340 | 0.81 | HPRT1 (0.43) | FGFR1SLC22A6HPRT1NT5ECYP3A4 | |
| SCHEMBL9858167 | 0.81 | FGFR1 (0.49) | FGFR1SLC22A6HPRT1NT5ECYP3A4 | |
| SCHEMBL9858162 | 0.80 | FGFR1 (0.59) | FGFR1SLC22A6CYP3A4ENPP1 | |
| Pmedap SCHEMBL29571667 | 0.77 | FGFR1 (0.72) | FGFR1SLC22A6HPRT1CYP3A4CDK1 | |
| Pmedap SCHEMBL215611 | 0.77 | FGFR1 (0.72) | FGFR1SLC22A6HPRT1CYP3A4CDK1 | |
| SCHEMBL9858344 | 0.76 | HPRT1 (0.58) | HPRT1POLBPNP | |
| SCHEMBL9858153 | 0.74 | FGFR1 (0.60) | FGFR1SLC22A6CYP3A4ENPP1AHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | claimed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | claimed |
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | disclosed |