⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31155734 | 0.75 | GAA (0.48) | — | |
| SCHEMBL28297 | 0.75 | GAA (0.48) | — | |
| SCHEMBL1449815 | 0.64 | GAA (0.36) | — | |
| SCHEMBL2320525 | 0.64 | GAA (0.36) | — | |
| SCHEMBL16427634 | 0.62 | GAA (0.44) | — | |
| SCHEMBL3873063 | 0.61 | — | — | |
| SCHEMBL1958600 | 0.59 | ALOX5 (0.34) | — | |
| SCHEMBL1087950 | 0.57 | GAA (0.68) | — | |
| SCHEMBL2493361 | 0.57 | — | — | |
| Iminostilbene SCHEMBL75288 | 0.57 | MAPT (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392407-A1 | SPIRO INDOLINE INHIBITORS OF KIF18A | Volastra Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2024137981-A1 | NAMPT MODULATORS | CYTOKINETICS, INCORPORATED (US) | 2024-06-27 | — | — | WO | disclosed |
| EP-3740481-B1 | DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2024-06-26 | — | — | EP | disclosed |
| EP-3634966-B1 | COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3 | NAT UNIV SINGAPORE (SG) | 2024-06-05 | — | — | EP | disclosed |
| CN-118103352-A | Spiroindoline inhibitors of KIF18A | 沃拉斯查疗法公司 | 2024-05-28 | — | — | CN | disclosed |
| US-11981644-B2 | Bicyclic 1,4-diazepanones and therapeutic uses thereof | CYTOKINETICS, INC. (US) | 2024-05-14 | — | — | US | disclosed |
| CN-117964573-A | Dihydrobenzofuran and indene analogs as myocardial segment inhibitors | 赛特凯恩蒂克公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117924208-A | Dihydrobenzofuran and indene analogs as myocardial segment inhibitors | 赛特凯恩蒂克公司 | 2024-04-26 | — | — | CN | disclosed |
| US-11964967-B2 | Cardiac sarcomere inhibitors | CYTOKINETICS, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| US-11952381-B2 | Cardiac sarcomere inhibitors | CYTOKINETICS, INC. (US) | 2024-04-09 | — | — | US | disclosed |
| EP-2049556-A1 | NEW MACROLIDES USEFUL AGAINST INFLAMMATORY AND ALLERGIC DISSEASES | Basilea Pharmaceutica AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| US-20080214589-A1 | Thrombin Inhibiting 2,4-Dioxo-3,4-Dihydropyrimidine Derivatives | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | US | disclosed |
| EP-1893600-A1 | TROMBIN INHIBITING 2,4-DIOXO-3,4-DIHYDROPYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2008017696-A1 | NEW MACROLIDES USEFUL AGAINST INFLAMMATORY AND ALLERGIC DISSEASES | BASILEA PHARMACEUTICA AG (CH) | 2008-02-14 | — | — | WO | disclosed |
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| US-20070099962-A1 | 5,6-Dihydropyrin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-05-03 | — | — | US | disclosed |
| WO-2007039170-A1 | ANTAGONISTS OF TOPOISOMERASE ACTIVITY AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2007-04-12 | — | — | WO | disclosed |
| WO-2006135312-A1 | TROMBIN INHIBITING 2,4-DIOXO-3,4-DIHYDROPYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |
| EP-1697323-A1 | NEW 5,6-DIHYDROPYRIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058826-A1 | NEW 5,6-DIHYDROPYRIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | ASTRAZENECA AB (SE) | 2005-06-30 | — | — | WO | disclosed |