SCHEMBL9860412

SCHEMBL9860412

O=C(Cl)c1cc2cc3cc(C(=O)Cl)c(C(=O)Cl)cc3cc2cc1C(=O)Cl

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.39
ALDH1A1 P00352 2/20 0.39
ALOX15 P16050 1/20 0.39
GPR35 Q9HC97 3/20 0.31
MEN1 O00255 1/20 0.31
MITF O75030 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
NCOA1 Q15788 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
IDO1 P14902 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL338945 0.83 ALDH1A1 (0.43) MAOBALDH1A1ALOX15MAPT
SCHEMBL1958554 0.80 ALDH1A1 (0.50) MAOBALDH1A1ALOX15GPR35MEN1
SCHEMBL29752028 0.80 ALDH1A1 (0.50) MAOBALDH1A1ALOX15GPR35MEN1
SCHEMBL11214665 0.75 MAPT (0.59) ALDH1A1MEN1MITFGAAMAPT
SCHEMBL7656107 0.75 ALDH1A1 (0.42) MAOBALDH1A1ALOX15MEN1MAPT
SCHEMBL7047489 0.73 ALDH1A1 (0.41) ALDH1A1ALOX15KMT2A
SCHEMBL11316478 0.73 ALDH1A1 (0.41) ALDH1A1ALOX15KMT2A
SCHEMBL11703883 0.73 ALDH1A1 (0.41) ALDH1A1ALOX15KMT2A
SCHEMBL895353 0.73 ALDH1A1 (0.41) ALDH1A1ALOX15KMT2A
SCHEMBL2265112 0.73 ALOX15 (0.37) MAOBALDH1A1ALOX15MEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0229470-B1 BRANCHED COPOLYETHERKETONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-30 EP disclosed
US-4720537-A Branched copolyetherketones E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-19 US disclosed
EP-0229470-A1 Branched copolyetherketones E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-22 EP disclosed