SCHEMBL9861767

SCHEMBL9861767

O=C(c1ccccc1)C(F)(Cl)Cl

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 0.67
ALDH1A1 P00352 4/20 0.46
CES2 O00748 3/20 0.46
TSHR P16473 2/20 0.46
DAO P14920 1/20 0.46
NAPRT Q6XQN6 1/20 0.46
SRC P12931 1/20 0.44
MAPK1 P28482 2/20 0.43
TRPA1 O75762 1/20 0.43
GSK3B P49841 1/20 0.43
HIF1A Q16665 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 2/20 0.42
MAPT P10636 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
CA2 P00918 2/20 0.42
CA4 P22748 2/20 0.42
POLB P06746 1/20 0.42
PARP1 P09874 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL855642 0.86 CES1 (0.67) CES1ALDH1A1CES2TSHRDAO
SCHEMBL5158726 0.82 CES1 (0.61) CES1ALDH1A1CES2TSHRDAO
SCHEMBL28445929 0.82 CES1 (0.61) CES1ALDH1A1CES2TSHRDAO
SCHEMBL33083 0.80 CES1 (1.00) CES1ALDH1A1CES2TSHRDAO
SCHEMBL132067 0.80 CES1 (0.58) CES1ALDH1A1CES2TSHRDAO
Benzene SCHEMBL27672585 0.80 CES1 (1.00) CES1ALDH1A1CES2TSHRDAO
SCHEMBL7907262 0.80 CES1 (0.73) CES1ALDH1A1CES2TSHRDAO
SCHEMBL11183801 0.80 CES1 (0.58) CES1ALDH1A1CES2TSHRDAO
SCHEMBL27938670 0.79 CES1 (0.64) CES1ALDH1A1CES2TSHRDAO
SCHEMBL28741013 0.79 CES1 (0.57) CES1ALDH1A1CES2TSHRDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0411252-A1 Process for the preparation of fluorobenzoic acids RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1991-02-06 EP disclosed