Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL554944 | 0.96 | TGFBR1 (0.48) | TGFBR1MMP1MMP2MMP3SMN1; SMN2 | |
| SCHEMBL12169104 | 0.80 | EPHX1 (0.42) | TGFBR1MMP1MMP2MMP3SMN1; SMN2 | |
| SCHEMBL16312318 | 0.79 | MMP1 (0.56) | MMP1MMP2MMP3SMN1; SMN2PKM | |
| SCHEMBL472264 | 0.79 | TGFBR1 (0.46) | TGFBR1SMN1; SMN2ALDH1A1RAB9AKMT2A | |
| SCHEMBL9193899 | 0.78 | TGFBR1 (0.59) | TGFBR1ALDH1A1KDM4E | |
| SCHEMBL18641077 | 0.78 | TGFBR1 (0.48) | TGFBR1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL24192977 | 0.78 | MMP1 (0.50) | MMP1MMP2MMP3SMN1; SMN2PKM | |
| SCHEMBL12296311 | 0.78 | MMP1 (0.50) | MMP1MMP2MMP3SMN1; SMN2PKM | |
| SCHEMBL13085203 | 0.78 | MMP1 (0.50) | MMP1MMP2MMP3SMN1; SMN2PKM | |
| SCHEMBL8300132 | 0.78 | MMP1 (0.50) | MMP1MMP2MMP3SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446469-A1 | Flame retardant polyacrylnitrile-(Co)-polymers containing phosphorus - containing derivatives of phenols | BAYER AG (DE) | 1991-09-18 | — | — | EP | disclosed |