Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 8/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9862534 | 0.81 | ESR1 (0.55) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL9862642 | 0.79 | CNR2 (0.51) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL31367881 | 0.77 | ESR1 (0.79) | HDAC1HDAC3HDAC2HDAC8NCOR2 | |
| SCHEMBL31367886 | 0.74 | ESR1 (0.76) | HDAC1ESR1CNR1HSD17B10MEN1 | |
| SCHEMBL7193607 | 0.74 | ESR1 (0.63) | ESR1TRPV1HSD17B10MEN1MAPT | |
| SCHEMBL7194125 | 0.74 | ESR1 (0.63) | ESR1TRPV1HSD17B10MEN1MAPT | |
| SCHEMBL7193335 | 0.74 | ESR1 (0.63) | ESR1TRPV1HSD17B10MEN1MAPT | |
| SCHEMBL31367878 | 0.72 | ESR1 (0.76) | HDAC1ESR1CNR1HSD17B10MEN1 | |
| SCHEMBL8366228 | 0.72 | HSD17B10 (0.69) | TRPV1CNR1HSD17B10MEN1MAPT | |
| SCHEMBL7271459 | 0.70 | GPR119 (0.64) | ESR1TRPV1CNR1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021414-A | Antiestrogen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-06-04 | — | — | US | disclosed |
| US-4904661-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-27 | — | — | US | disclosed |
| US-4732912-A | ANTIESTROGENS, ANTITUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-03-22 | — | — | US | disclosed |
| EP-0124369-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-24 | — | — | EP | disclosed |
| EP-0124369-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-11-07 | — | — | EP | disclosed |