Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9862532 | 0.85 | ESR1 (0.42) | LMNAMAPTBCHEACHESMN1; SMN2 | |
| SCHEMBL9862577 | 0.82 | ALDH1A1 (0.45) | LMNASMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL9862381 | 0.82 | ALDH1A1 (0.45) | LMNASMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL9862689 | 0.78 | CYP4F2 (0.45) | LMNAMAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9862564 | 0.77 | FFAR1 (0.50) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9862517 | 0.76 | FFAR1 (0.51) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9862483 | 0.75 | PTGS1 (0.53) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9862466 | 0.75 | PTGS1 (0.53) | LMNAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL10451931 | 0.74 | FFAR1 (0.48) | LMNAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9863683 | 0.74 | CYP3A4 (0.48) | LMNAMAPTSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021414-A | Antiestrogen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-06-04 | — | — | US | disclosed |
| US-4904661-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-27 | — | — | US | disclosed |
| US-4732912-A | ANTIESTROGENS, ANTITUMOR AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-03-22 | — | — | US | disclosed |
| EP-0124369-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-24 | — | — | EP | disclosed |