Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 13/20 | 0.43 |
| ▸ | F13A1 | P00488 | 11/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TGM1 | P22735 | 8/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988287 | 0.83 | MEN1 (0.45) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL31399716 | 0.82 | CHRM1 (0.54) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL31399717 | 0.82 | CHRM1 (0.54) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL31399710 | 0.81 | ALDH1A1 (0.49) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL987296 | 0.80 | ROCK2 (0.59) | SMN1; SMN2KDM4EHTTROCK2PRKX | |
| SCHEMBL31399689 | 0.78 | TGM2 (0.44) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL31399725 | 0.77 | TSHR (0.50) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4266289 | 0.76 | CNR1 (0.59) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL1039708 | 0.76 | ROCK2 (0.71) | SMN1; SMN2ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL31399732 | 0.75 | ALDH1A1 (0.65) | TGM2F13A1SMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |