Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 9/20 | 0.45 |
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864012 | 0.90 | PTAFR (0.41) | PTAFRBRD4MAPK1OPRK1PDE4D | |
| SCHEMBL9864263 | 0.89 | PTAFR (0.47) | PTAFRBRD4MAPK1OPRK1PDE4D | |
| SCHEMBL9472598 | 0.84 | PTAFR (0.56) | PTAFROPRK1PDE4D | |
| SCHEMBL9864306 | 0.83 | BRD4 (0.44) | PTAFRBRD4OPRK1PDE4D | |
| SCHEMBL9864632 | 0.82 | PTAFR (0.43) | PTAFRBRD4OPRK1PDE4D | |
| SCHEMBL9864670 | 0.81 | PTAFR (0.43) | PTAFRBRD4OPRK1PDE4D | |
| SCHEMBL9863786 | 0.81 | HDAC3 (0.48) | PTAFRBRD4OPRK1 | |
| SCHEMBL9864373 | 0.80 | BRD4 (0.43) | PTAFRBRD4OPRK1PDE4D | |
| SCHEMBL12228314 | 0.79 | PGR (0.45) | PTAFRBRD4OPRK1PDE4D | |
| SCHEMBL9864382 | 0.79 | PTAFR (0.52) | PTAFROPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407955-A1 | New hetrazepines acting as PAF antagonists, process for their production and their use as drugs | BOEHRINGER INGELHEIM KG (DE) | 1991-01-16 | — | — | EP | disclosed |