Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 10/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864306 | 0.94 | BRD4 (0.44) | PTAFRPGRHTR1AADRA2AADORA3 | |
| SCHEMBL9864632 | 0.93 | PTAFR (0.43) | PTAFRPGRHTR1AADRA2AADORA3 | |
| SCHEMBL9864670 | 0.92 | PTAFR (0.43) | PTAFRPGRHTR1AADRA2AADORA3 | |
| SCHEMBL9863786 | 0.91 | HDAC3 (0.48) | PTAFRMEN1ALDH1A1POLBHTT | |
| SCHEMBL12228314 | 0.91 | PGR (0.45) | PTAFRPGRHTR1AADRA2AADORA3 | |
| SCHEMBL9864382 | 0.90 | PTAFR (0.52) | PTAFRMEN1ALDH1A1POLBHTT | |
| SCHEMBL9864007 | 0.89 | PTAFR (0.45) | PTAFRBRD4OPRK1PDE4DMAPK1 | |
| SCHEMBL9863710 | 0.89 | HDAC3 (0.41) | PTAFRMEN1ALDH1A1POLBHTT | |
| SCHEMBL9864142 | 0.89 | PTAFR (0.43) | PTAFRMEN1ALDH1A1POLBHTT | |
| SCHEMBL9872279 | 0.88 | HDAC3 (0.43) | PTAFRPGRHTR1AADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407955-A1 | New hetrazepines acting as PAF antagonists, process for their production and their use as drugs | BOEHRINGER INGELHEIM KG (DE) | 1991-01-16 | — | — | EP | disclosed |