Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864296 | 0.89 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864482 | 0.87 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864044 | 0.84 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9863893 | 0.84 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864455 | 0.77 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864575 | 0.77 | SLC6A4 (0.56) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864477 | 0.76 | SLC6A3 (0.44) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864235 | 0.75 | SLC6A4 (0.53) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864684 | 0.74 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864282 | 0.74 | SLC6A4 (0.38) | SLC6A4SLC6A3SLC6A2HSD11B1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |