Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9863981 | 0.89 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2KDM1AALDH1A1 | |
| SCHEMBL9864069 | 0.86 | SLC6A4 (0.33) | SLC6A4SLC6A3SLC6A2KDM1AALDH1A1 | |
| SCHEMBL9864296 | 0.85 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL9864286 | 0.85 | SLC6A3 (0.43) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL9863748 | 0.84 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL9863950 | 0.77 | SLC6A4 (0.61) | SLC6A4SLC6A3SLC6A2ALDH1A1HTR2A | |
| SCHEMBL872383 | 0.77 | TP53 (0.56) | SLC6A4SLC6A3SLC6A2KDM1AALDH1A1 | |
| SCHEMBL9863833 | 0.75 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864713 | 0.75 | SLC6A3 (0.42) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864213 | 0.74 | SLC6A4 (0.47) | SLC6A4SLC6A3SLC6A2KDM1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |