Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864227 | 0.89 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864482 | 0.89 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864282 | 0.85 | SLC6A4 (0.38) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL9863950 | 0.85 | SLC6A4 (0.61) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9863748 | 0.84 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864286 | 0.77 | SLC6A3 (0.43) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| Fumaric Acid SCHEMBL9864009 | 0.77 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| Maleic Acid SCHEMBL9863998 | 0.77 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864068 | 0.75 | SLC6A4 (0.58) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL9864232 | 0.75 | SLC6A4 (0.58) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |