Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864282 | 0.86 | SLC6A4 (0.38) | SLC6A4SLC6A3SLC6A2CYP2C19ALDH1A1 | |
| SCHEMBL9863981 | 0.82 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2CYP2C19ALDH1A1 | |
| SCHEMBL9864088 | 0.81 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2ALDH1A1 | |
| SCHEMBL9864312 | 0.76 | TP53 (0.37) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864669 | 0.75 | TP53 (0.36) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864296 | 0.72 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864713 | 0.72 | SLC6A3 (0.42) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864286 | 0.71 | SLC6A3 (0.43) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9863748 | 0.71 | SLC6A4 (0.42) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL872383 | 0.71 | TP53 (0.56) | SLC6A4SLC6A3SLC6A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |