Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864273 | 0.91 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 | |
| SCHEMBL9864332 | 0.81 | CASR (0.44) | OPRM1OPRL1 | |
| SCHEMBL9864359 | 0.78 | SLC6A4 (0.48) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 | |
| SCHEMBL9118387 | 0.77 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 | |
| SCHEMBL9863999 | 0.77 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL9863909 | 0.76 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 | |
| SCHEMBL9864123 | 0.76 | SLC6A3 (0.57) | SLC6A4SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL9864247 | 0.75 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CCR2OPRM1 | |
| SCHEMBL9864171 | 0.74 | SLC6A2 (0.46) | SLC6A4SLC6A3SLC6A2OPRM1OPRK1 | |
| SCHEMBL9863806 | 0.74 | SLC6A4 (0.53) | SLC6A4SLC6A3SLC6A2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |