Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | TACR3 | P29371 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864129 | 0.83 | CASR (0.41) | CASROPRM1OPRL1TACR1TACR3 | |
| SCHEMBL9864259 | 0.82 | CHRM2 (0.45) | TACR3 | |
| SCHEMBL9864288 | 0.81 | SLC6A4 (0.47) | OPRM1OPRL1 | |
| SCHEMBL10638666 | 0.79 | TACR3 (0.33) | CASROPRM1OPRL1TACR1TACR3 | |
| SCHEMBL9864273 | 0.73 | SLC6A4 (0.46) | OPRM1OPRL1ALDH1A1 | |
| SCHEMBL9864359 | 0.65 | SLC6A4 (0.48) | OPRM1OPRL1OPRD1 | |
| SCHEMBL9118387 | 0.65 | SLC6A4 (0.52) | OPRM1OPRL1 | |
| SCHEMBL9864574 | 0.64 | SLC6A3 (0.49) | — | |
| SCHEMBL9863909 | 0.64 | SLC6A4 (0.46) | OPRM1OPRL1OPRD1 | |
| SCHEMBL12125729 | 0.64 | KMT2A (0.64) | KMT2AEPHX2TRPV4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |