Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447380 | 0.85 | MAPT (0.51) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3406385 | 0.83 | HDAC4 (0.53) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1769960 | 0.82 | HDAC4 (0.54) | HSD11B1HDAC4SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2550 | 0.82 | HDAC4 (0.54) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4945510 | 0.82 | HSD11B1 (0.48) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4945514 | 0.81 | HSD11B1 (0.47) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1770373 | 0.80 | HDAC4 (0.56) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3443916 | 0.80 | HDAC4 (0.56) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2328536 | 0.80 | HSD11B1 (0.46) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1758 | 0.79 | HDAC4 (0.51) | HSD11B1HDAC4SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |