Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866597 | 0.94 | PBRM1 (0.37) | PBRM1CYP19A1ESR2ESR1KDM4E | |
| SCHEMBL9602844 | 0.92 | ACHE (0.35) | CYP19A1ESR2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9601978 | 0.91 | MEN1 (0.35) | ESR2ALDH1A1MAPTPTGS2KMT2A | |
| SCHEMBL9601954 | 0.91 | MAOB (0.40) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL10660494 | 0.91 | KDM4E (0.34) | PBRM1CYP19A1ESR2ESR1KDM4E | |
| SCHEMBL9865118 | 0.87 | EP300 (0.35) | ESR2ESR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL10367579 | 0.85 | PRKCZ (0.41) | CYP19A1ESR2ESR1KDM4ENPC1 | |
| SCHEMBL9865424 | 0.85 | MIF (0.40) | CYP19A1ESR2ESR1ALDH1A1GLA | |
| SCHEMBL10365809 | 0.84 | ACHE (0.38) | KDM4ENPC1ALDH1A1GLAGAA | |
| SCHEMBL9601936 | 0.81 | MAOB (0.40) | ESR2ESR1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |