Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867126 | 0.86 | HRH4 (0.47) | HRH4HRH3HTR3A | |
| SCHEMBL7430491 | 0.83 | EBP (0.40) | — | |
| SCHEMBL9866256 | 0.83 | HRH4 (0.47) | HRH4HRH3HTR3A | |
| SCHEMBL9867357 | 0.82 | SCN5A (0.43) | HRH4HRH3 | |
| SCHEMBL9865196 | 0.82 | HRH2 (0.41) | HRH4SMN1; SMN2LMNAHTT | |
| SCHEMBL9865107 | 0.81 | SMN1; SMN2 (0.40) | HRH4HRH3SMN1; SMN2LMNAHTT | |
| SCHEMBL7433411 | 0.80 | — | — | |
| Iodide SCHEMBL10369053 | 0.80 | SMN1; SMN2 (0.40) | HRH4HRH3SMN1; SMN2LMNAHTT | |
| SCHEMBL9865960 | 0.80 | SCN5A (0.42) | HRH4HRH3 | |
| SCHEMBL11039972 | 0.79 | GRIN2D (0.41) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |