Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866042 | 0.90 | SCN5A (0.44) | LMNAALDH1A1SMN1; SMN2HRH4HRH3 | |
| SCHEMBL9868525 | 0.88 | SIGMAR1 (0.44) | LMNAALDH1A1MAPTHRH4HRH3 | |
| SCHEMBL9876542 | 0.87 | HRH4 (0.39) | SMN1; SMN2HRH4HRH3HRH2HTT | |
| SCHEMBL7178167 | 0.86 | HRH4 (0.41) | HRH4HRH3HRH2 | |
| SCHEMBL9867274 | 0.85 | MC3R (0.37) | LMNAALDH1A1SMN1; SMN2HRH4HRH3 | |
| SCHEMBL9865256 | 0.84 | ALDH1A1 (0.45) | LMNAALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL7175060 | 0.82 | HRH2 (0.40) | HRH4HRH3HRH2 | |
| SCHEMBL9171834 | 0.82 | HRH4 (0.41) | HRH4HRH3HRH2 | |
| SCHEMBL10371006 | 0.82 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MAPTHRH4HRH3 | |
| Impromidine SCHEMBL7171550 | 0.82 | HRH4 (0.44) | HRH4HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |