Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC3R | P41968 | 3/20 | 0.37 |
| ▸ | MC1R | Q01726 | 3/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10371006 | 0.86 | ALDH1A1 (0.41) | HRH4HRH3SIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9865263 | 0.85 | LMNA (0.41) | HRH4HRH3HRH2ALDH1A1IDO1 | |
| SCHEMBL9866042 | 0.85 | SCN5A (0.44) | HRH4HRH3EBPSIGMAR1HRH2 | |
| SCHEMBL9868525 | 0.85 | SIGMAR1 (0.44) | HRH4HRH3SIGMAR1HRH2ALDH1A1 | |
| SCHEMBL7178167 | 0.84 | HRH4 (0.41) | HRH4HRH3EBPSIGMAR1HRH2 | |
| SCHEMBL9876542 | 0.84 | HRH4 (0.39) | HRH4HRH3EBPSIGMAR1HRH2 | |
| SCHEMBL9866789 | 0.83 | CYP1A2 (0.38) | HRH4HRH3EBPSIGMAR1HRH2 | |
| SCHEMBL9866134 | 0.83 | SCN5A (0.37) | MC3RMC1RMC4RHRH2SCN5A | |
| SCHEMBL9866141 | 0.83 | SCN5A (0.37) | MC3RMC1RMC4RHRH2SCN5A | |
| SCHEMBL9868660 | 0.83 | TRPV1 (0.39) | HRH4HRH3SCN5ASCN2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |