SCHEMBL9865845

SCHEMBL9865845

O=C(NC(=NCCSCc1cccc2ccccc12)NCCCc1c[nH]cn1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.36
ALDH1A1 P00352 3/20 0.35
HPGD P15428 2/20 0.35
HTR1A P08908 1/20 0.34
DRD2 P14416 1/20 0.34
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
DRD3 P35462 1/20 0.34
SCN5A Q14524 3/20 0.34
SCN2A Q99250 3/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CYP2D6 P10635 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HRH2 P25021 2/20 0.34
MTNR1A P48039 2/20 0.33
TRPV1 Q8NER1 1/20 0.33
NQO2 P16083 1/20 0.33
MTNR1B P49286 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10368541 1.00 CYP1A2 (0.36) CYP1A2ALDH1A1HPGDHTR1ADRD2
SCHEMBL9865848 0.94 ALDH1A1 (0.39) CYP1A2ALDH1A1HPGDSCN5ASCN2A
SCHEMBL9867644 0.87 SCN5A (0.45) ALDH1A1HPGDSCN5ASCN2ASMN1; SMN2
SCHEMBL9867640 0.87 SCN5A (0.45) ALDH1A1HPGDSCN5ASCN2ASMN1; SMN2
SCHEMBL9866419 0.87 RAB9A (0.42) CYP1A2ALDH1A1SCN5ASCN2ACYP2C19
SCHEMBL9866134 0.85 SCN5A (0.37) SCN5ASCN2ASMN1; SMN2HRH2MTNR1B
SCHEMBL9866505 0.85 PSMB5 (0.44) HTR1ADRD2HTR2AHTR2CDRD3
SCHEMBL9866141 0.85 SCN5A (0.37) SCN5ASCN2ASMN1; SMN2HRH2MTNR1B
SCHEMBL9867007 0.84 SCN5A (0.40) CYP1A2ALDH1A1SCN5ASCN2ACYP2C9
SCHEMBL9865157 0.84 ALDH1A1 (0.44) ALDH1A1HPGDSCN5ASCN2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5021431-A H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion HEUMANN PHARMA GMBH & CO. (DE) 1991-06-04 US disclosed
EP-0199845-B1 IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HEUMANN PHARMA GMBH & CO (DE) 1990-08-01 EP disclosed
EP-0199845-A1 Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them HEUMANN PHARMA GMBH & CO (DE) 1986-11-05 EP disclosed