Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.55 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865777 | 0.88 | PDE10A (0.59) | PDE10ACYSLTR2CYSLTR1ADAMTS4GPBAR1 | |
| SCHEMBL9866285 | 0.88 | PDE10A (0.62) | PDE10ACYSLTR2CYSLTR1GPBAR1ALOX5 | |
| SCHEMBL9866102 | 0.81 | CYSLTR2 (0.52) | PDE10ACYSLTR2CYSLTR1ADAMTS4ALOX5 | |
| SCHEMBL9876648 | 0.78 | CYSLTR2 (0.60) | PDE10ACYSLTR2CYSLTR1ADAMTS4GPBAR1 | |
| SCHEMBL9018929 | 0.78 | CYSLTR2 (0.54) | PDE10ACYSLTR2CYSLTR1ADAMTS4GPBAR1 | |
| SCHEMBL9865805 | 0.76 | CYSLTR1 (0.48) | PDE10ACYSLTR2CYSLTR1ADAMTS4GPBAR1 | |
| SCHEMBL3362235 | 0.74 | CYSLTR1 (0.63) | CYSLTR2CYSLTR1ADAMTS4GPBAR1 | |
| SCHEMBL9866291 | 0.73 | CYSLTR1 (0.52) | PDE10ACYSLTR2CYSLTR1ADAMTS4GPBAR1 | |
| SCHEMBL9508040 | 0.73 | CYSLTR1 (0.60) | CYSLTR2CYSLTR1ADAMTS4ALOX5 | |
| SCHEMBL7751226 | 0.73 | CYSLTR2 (0.57) | PDE10ACYSLTR2CYSLTR1ADAMTS4GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045547-A | Leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas and use thereas | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |