SCHEMBL9866005

SCHEMBL9866005

N#Cc1sc([S+]([O-])Cc2ccccc2)c(C#N)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
ADORA1 P30542 1/20 0.31
KDM4E B2RXH2 2/20 0.31
LMNA P02545 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
POLB P06746 2/20 0.30
MEN1 O00255 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30
HPGD P15428 1/20 0.30
CYP2C19 P33261 1/20 0.30
PPARG P37231 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30
NCOA2 Q15596 1/20 0.30
NCOA1 Q15788 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9866238 0.80
SCHEMBL9865758 0.78 GRM6 (0.32) ALDH1A1
SCHEMBL20359 0.76
SCHEMBL9865543 0.74
SCHEMBL9865594 0.72
SCHEMBL9865724 0.71 MEN1 (0.32) ALDH1A1SMN1; SMN2MEN1HPGDKMT2A
SCHEMBL11561226 0.69 ALDH1A1 (0.36) ALDH1A1SMN1; SMN2TAAR1KDM4EMEN1
SCHEMBL11559654 0.68 SQOR (0.38) ALDH1A1SMN1; SMN2TAAR1ADORA1MEN1
SCHEMBL9865156 0.67 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2ADORA1KDM4ELMNA
SCHEMBL9864829 0.65 CYP1A2 (0.35) ALDH1A1SMN1; SMN2KDM4EMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1017243-B THIO COMPOUNDS HAVING FUNGICIDAL ACTIVITY DUPHAR INT RES (NL) 1992-07-01 CN disclosed
US-4994485-A Seed and soil fungi, bacteria DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1991-02-19 US disclosed
EP-0234622-B1 NEW THIO COMPOUNDS HAVING FUNGICIDAL ACTIVITY DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1990-06-27 EP disclosed
CN-87101917-A Has the active novel sulfurized compound of antifungal 1988-01-06 CN disclosed
EP-0234622-A1 New thio compounds having fungicidal activity DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1987-09-02 EP disclosed