Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868517 | 0.89 | KMT2A (0.42) | GAAALOX12ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9868656 | 0.85 | TRPV1 (0.45) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9867267 | 0.84 | LMNA (0.35) | GAAALOX12ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10371006 | 0.83 | ALDH1A1 (0.41) | GAAALOX12ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9876539 | 0.83 | CYP1A2 (0.38) | GAAALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL9867335 | 0.83 | EPHX2 (0.35) | ALDH1A1HPGDSMN1; SMN2LMNAIDO1 | |
| SCHEMBL9866034 | 0.82 | ALDH1A1 (0.45) | GAAALOX12ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7175108 | 0.80 | SLC47A1 (0.31) | ALDH1A1 | |
| SCHEMBL9865256 | 0.80 | ALDH1A1 (0.45) | GAAALOX12ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7180733 | 0.79 | LMNA (0.37) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |