Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867905 | 0.89 | ADRB2 (0.44) | CYP2D6ADRB2ADRB1ADRB3TSHR | |
| SCHEMBL9867229 | 0.81 | TOP1 (0.40) | — | |
| SCHEMBL9865164 | 0.79 | MAOB (0.37) | CYP2D6TSHRHTR1ASLC6A4SIGMAR1 | |
| SCHEMBL9603116 | 0.79 | CYP2D6 (0.41) | CYP2D6ADRB2ADRB1ADRB3TSHR | |
| SCHEMBL9865298 | 0.74 | MCHR1 (0.43) | CYP2D6TSHRHTR1ASLC6A4SIGMAR1 | |
| SCHEMBL9866651 | 0.70 | ADRB2 (0.45) | CYP2D6ADRB2ADRB1ADRB3TSHR | |
| SCHEMBL9866045 | 0.69 | THRB (0.34) | MEN1KMT2A | |
| SCHEMBL9602957 | 0.68 | PTGS1 (0.42) | CYP2D6ADRB2ADRB1ADRB3TSHR | |
| SCHEMBL9865872 | 0.67 | ADRB2 (0.44) | ADRB2ADRB1ADRB3TSHRADRA1A | |
| SCHEMBL11167444 | 0.67 | MEN1 (0.53) | CYP2D6ADRB2ADRB1ADRB3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |