Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865013 | 1.00 | TDP1 (0.70) | TDP1MAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL9865921 | 1.00 | TDP1 (0.70) | TDP1MAPTLMNANPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9866120 | 0.99 | MAPT (0.70) | TDP1MAPTLMNANPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9865660 | 0.87 | TDP1 (0.70) | TDP1MAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL12575384 | 0.84 | MAPT (0.75) | MAPTLMNANPSR1ALDH1A1HTT | |
| SCHEMBL13719544 | 0.84 | MAPT (0.75) | MAPTLMNANPSR1ALDH1A1HTT | |
| SCHEMBL10983422 | 0.80 | ATM (0.74) | TDP1MAPTLMNAALDH1A1HTT | |
| SCHEMBL8434186 | 0.80 | LMNA (0.75) | TDP1MAPTLMNAALDH1A1HTT | |
| SCHEMBL2019517 | 0.79 | ADRB2 (0.72) | MAPTLMNANPSR1ALDH1A1HTT | |
| SCHEMBL2019520 | 0.79 | ADRB2 (0.72) | MAPTLMNANPSR1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994459-A | Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-02-19 | — | — | US | claimed |
| US-4994459-A | Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |