Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28067146 | 1.00 | TSHR (0.40) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL9866159 | 1.00 | TSHR (0.40) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL1231630 | 0.98 | LMNA (0.38) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL4522063 | 0.93 | SLC22A6 (0.39) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL3903619 | 0.86 | TSHR (0.36) | TSHRALDH1A1SLC22A6 | |
| SCHEMBL28073765 | 0.81 | HDAC2 (0.38) | ALDH1A1HDAC11 | |
| SCHEMBL25347728 | 0.79 | BLM (0.34) | PMP22HSD17B10 | |
| SCHEMBL6937746 | 0.75 | — | — | |
| SCHEMBL27529236 | 0.74 | GPR84 (0.48) | TSHRLMNAALDH1A1GPR84PPARG | |
| SCHEMBL3486016 | 0.74 | ALDH1A1 (0.44) | TSHRLMNANFKB1PMP22ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117751112-A | Heteroaryl-3-piperidinedione compounds and application thereof | 南京明德新药研发有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-116375713-A | DCLK1 protein degradation targeting chimeric and application thereof | 中国人民解放军海军军医大学 | 2023-07-04 | — | — | CN | disclosed |
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |