Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.49 |
| ▸ | ITGAL | P20701 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866499 | 1.00 | GLO1 (0.59) | GLO1ALDH1A1POLBCASP6CTDSP1 | |
| SCHEMBL10983993 | 0.79 | GLO1 (0.66) | GLO1ALDH1A1LMNACA1CA2 | |
| SCHEMBL10982646 | 0.79 | GLO1 (0.59) | GLO1ALDH1A1POLBCASP6CTDSP1 | |
| SCHEMBL11564904 | 0.77 | GLO1 (0.63) | GLO1ALDH1A1LMNACA1CA2 | |
| SCHEMBL10896757 | 0.76 | GLO1 (0.61) | GLO1ALDH1A1LMNACA1CA2 | |
| SCHEMBL10896764 | 0.76 | GLO1 (0.61) | GLO1ALDH1A1LMNACA1CA2 | |
| SCHEMBL10989985 | 0.76 | GLO1 (0.61) | GLO1ALDH1A1POLBLMNACA1 | |
| SCHEMBL3891229 | 0.75 | ATAD2 (0.42) | ALDH1A1POLBCASP6KMT2AMEN1 | |
| SCHEMBL8028846 | 0.75 | GLO1 (1.00) | GLO1ALDH1A1LMNAITGB2ICAM1 | |
| SCHEMBL10983080 | 0.74 | GLO1 (0.59) | GLO1ALDH1A1LMNACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994612-A | Intermediates for dihydropyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-02-19 | — | — | US | disclosed |
| US-4847273-A | CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0212107-A1 | Esters of 1,4-dihydro-5-sulfamoyl nicotinic acid | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-03-04 | — | — | EP | disclosed |