Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 7/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866702 | 0.93 | SCN5A (0.42) | SCN5ASCN2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9866696 | 0.93 | SCN5A (0.42) | SCN5ASCN2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9865291 | 0.89 | HRH2 (0.36) | SCN5ASCN2AHRH4HRH2 | |
| SCHEMBL9866993 | 0.89 | HRH2 (0.36) | HRH4HRH2 | |
| SCHEMBL9865732 | 0.87 | HPGD (0.52) | SCN5ASCN2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9866012 | 0.86 | LMNA (0.53) | SCN5ASCN2AALDH1A1HPGDLMNA | |
| SCHEMBL9865881 | 0.85 | HPGD (0.46) | SCN5ASCN2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7297991 | 0.84 | NPY1R (0.39) | SCN5ASCN2A | |
| SCHEMBL9710076 | 0.83 | EPHX2 (0.46) | CYP2C9HPGDCYP2C19HRH4LMNA | |
| SCHEMBL7431300 | 0.83 | EPHX2 (0.46) | CYP2C9HPGDCYP2C19HRH4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | claimed |
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |