Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867538 | 0.85 | SMN1; SMN2 (0.45) | L3MBTL1MAPK1SMN1; SMN2NPC1MAPT | |
| SCHEMBL10642054 | 0.80 | L3MBTL1 (0.38) | L3MBTL1MAPK1CYP1A2NR1H4CLK4 | |
| SCHEMBL9867104 | 0.79 | LMNA (0.40) | L3MBTL1MAPK1CYP1A2CLK4CYP2C19 | |
| SCHEMBL9867461 | 0.78 | L3MBTL1 (0.36) | L3MBTL1CYP1A2NR1H4CYP2C19SMN1; SMN2 | |
| SCHEMBL9867465 | 0.78 | L3MBTL1 (0.36) | L3MBTL1CYP1A2NR1H4CYP2C19SMN1; SMN2 | |
| SCHEMBL9867475 | 0.74 | CA1 (0.45) | L3MBTL1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL9867023 | 0.70 | NPC1 (0.41) | L3MBTL1MAPK1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL9867029 | 0.70 | NPC1 (0.41) | L3MBTL1MAPK1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL9866060 | 0.69 | MEN1 (0.44) | L3MBTL1MAPK1CYP1A2CLK4CYP2C19 | |
| SCHEMBL9866057 | 0.69 | MEN1 (0.44) | L3MBTL1MAPK1CYP1A2CLK4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |