Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867465 | 1.00 | L3MBTL1 (0.36) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9866761 | 0.88 | NPC1 (0.38) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9866764 | 0.88 | NPC1 (0.38) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9866126 | 0.86 | SMN1; SMN2 (0.48) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9866121 | 0.86 | SMN1; SMN2 (0.48) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10642054 | 0.80 | L3MBTL1 (0.38) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9867020 | 0.78 | L3MBTL1 (0.38) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9867475 | 0.72 | CA1 (0.45) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9867104 | 0.71 | LMNA (0.40) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9868490 | 0.70 | MEN1 (0.41) | L3MBTL1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |